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Cefalexin, also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections.
Cefalexin can treat certain bacterial infections, including those of the middle ear, bone and joint, skin, and urinary tract.
Common side effects include stomach upset and diarrhea.
In 2012, cefalexin was one of the top 100 most prescribed medications in the United States.
1 Medical uses
1.1 Pregnancy and breastfeeding
2 Adverse effects
3 Interactions
4 Pharmacology
4.1 Mechanism of action
4.2 Pharmacokinetics
5 Society and culture
5.1 Names
6 References
7 External links
Medical uses
A course of cefalexin capsules, commonly prescribed for infections
Cefalexin can treat a number of bacterial infections including: otitis media, streptococcal pharyngitis, bone and joint infections, pneumonia, cellulitis, and urinary tract infections.
Cefalexin does not treat methicillin-resistant Staphylococcus aureus infections.
Cefalexin is a useful alternative to penicillins in patients with penicillin intolerance. For example, penicillin is the treatment of choice for respiratory tract infections caused by Streptococcus, but cefalexin may be used as an alternative in penicillin-intolerant patients.
Pregnancy and breastfeeding
It is pregnancy category B in the United States and category A in Australia, meaning that no evidence of harm has been found after being taken by many pregnant women.
Adverse effects
The most common adverse effects of cefalexin, like other oral cephalosporins, are gastrointestinal (stomach area) disturbances and hypersensitivity reactions. Gastrointestinal disturbances include nausea, vomiting, and diarrhea, diarrhea being most common.
Signs and symptoms of an allergic reaction include rash, itching, swelling, trouble breathing, or red, blistered, swollen, or peeling skin. Overall, cefalexin allergy occurs in less than 0.1% of patients, but it is seen in 1% to 10% of patients with a penicillin allergy.
Like other β-lactam antibiotics, renal excretion of cefalexin is delayed by probenecid.
Mechanism of action
Cefalexin is a beta-lactam antibiotic of the cephalosporin family.
Like most other cephalosporins, cefalexin is not metabolized or otherwise inactivated in the body.
Society and culture
Cefalexin is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a health system.
Cefalexin is the INN and BAN while cephalexin is the USAN and AAN.
Common brand names for cefalexin include Keflex, Cepol, Ceporexine, Ceporex, Cefadal, Derantel, Mecilex, Medoxine, Sporibest (Bionova), Xahl, and Tokiolexin.

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